Well, Rockstar has determined when I'm taking my vacation this spring: April 29 release date for GTA IV. Judging from the demo writeups, the game is well on track for that date. A few people I know in the biz who are in a position to know have nothing but good things to say about the game, so my interest level couldn't be higher. Until then, replays of San Andreas and Saints Row will have to suffice.
If GTA IV, Saints Row 2, and Mercenaries 2 all ship this year, 2008 will be an unimaginably good year for open-world games.