I'm really excited about the upcoming release of Bioshock, as you might imagine given my past relationship to Irrational Games and to the "inspiration source material" of the System Shock games. For a game like this that I know is just going to fire on all cylinders for me, I actively try to avoid spoilers. It's getting hard -- I'm hearing some great reviews on the game from a number of sources and friends keep sending me preview video links that I'm sorely tempted to watch. Of course, a certain amount of spoiler-corruption is inevitable... I know a bit about some game mechanics and enemies just from basic promotional materials. Now I only have another two weeks to hold out so hopefully I can stay spoiler free.
I find it an interesting contrast to GTA IV, where I want to know every scrap of data I can. I'm not quite sure how to explain the difference in my mind -- I think it is for the same reasons that I so enjoy replaying the GTA games. At its best GTA for me is about a sense of space, so learning about the world ahead of time just makes that space resonate more strongly when I'm really exploring it in 3d. There is so much explorational content in the game that the promotional materials don't even touch. Actually experiencing it is so different than watching trailers or delving through interactive websites that the "spoiler" factor is quite low.